Data Using Our Products Presented at International Conference on SMALP (Styrene-Maleic Acid Lipid Particles)

by Ai Kano, Tuesday, 12th May 2020

On March 20, Verna Frasca from Malvern Panalytical gave a presentation at the SMALP2020 Web conference.

Styrene-maleic acid lipid particles (SMALP) are nanodiscs created from the interaction of the membrane bilayer and styrene-maleic acid (SMA) copolymers. SMA and other related amphiphilic polymers naturally solubilize membranes to form SMALP.

During the formation of SMALP containing membrane proteins, traditional surfactants usually used for solubilization are not required. SMALP holds great potential as biochemical and biophysical tools that allow native membrane proteins to maintain their activity and structure. Since SMALP can retain membrane lipids, it enables the assessment of functional, biophysical, and structural characteristics of native membrane protein complexes. SMALP may also impact drug delivery system (DDS) technology.

SMALP network is an international consortium of researchers and industry focused on the development of SMALP technology, materials, and best practices. Although plans were affected by the COVID-19 pandemic, the international conference was held on March 20 via Zoom.

The main presentation themes were as follows:

  • Stabilization of membrane proteins for biophysical and structural characterization using SMALP (including Cryo-EM)
  • Advancements in polymer design
  • Best practices for SMALP formation and analysis.

Verna Frasca from Malvern Panalytical presented in the fifth session of this conference on the theme of biophysical analysis of SMALP using data from Zetasizer, Omnisec, MicroCal ITC and MicroCal DSC.

※Click here to view the data presented by our company (Document in English) ※

Additionally, the SMALP network is planning to hold web-based conferences on June 19 and September 18.

※For conference participation or to register on the SMALP network mailing list, click here (external site) ※

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