Gel Permeation Chromatography (GPC) is an analytical technique that separates dissolved macromolecules by size based on their elution from columns filled with a porous gel.

When GPC is coupled with light scattering, viscometer and concentration detectors (known as triple detection), it can measure absolute molecular weight, molecular size and intrinsic viscosity, and generate information on macromolecular structure, conformation, aggregation and branching.

By using GPC to measure molecular weight and these other properties, scientists can characterize molecules such as synthetic polymers, as well as natural polymers such as polysaccharides.

For all of these molecules, these parameters relate very closely to their performance in countless applications. With this technique:

  • Polymer chemists can control polymer strength, toughness and performance.
  • Pharmaceutical producers can tailor the behavior of products such as eye-drops.
  • Food producers can better understand product performance and quality.

From novel polymers to polymer formulations and additives, in applications from paints and coatings to foods and pharmaceuticals, Malvern offers a range of GPC systems or individual GPC detectors including SEC-MALS to suit your application needs.

OMNISEC

OMNISEC

The world’s most advanced multi-detector GPC/SEC system

More details
Measurement Molecular structure, Molecular size, Molecular weight
Molecular weight range 200Da - 10MDa
Minimum sample mass (polystyrene) 100ng
Minimum sample mass (BSA) 100ng
Technology Gel Permeation Chromatography, Size Exclusion Chromatography (SEC), Light Scattering, Static Light Scattering

OMNISEC

OMNISEC

The world’s most advanced multi-detector GPC/SEC system

More details
Measurement Molecular structure, Molecular size, Molecular weight
Molecular weight range 200Da - 10MDa
Minimum sample mass (polystyrene) 100ng
Minimum sample mass (BSA) 100ng
Technology Gel Permeation Chromatography, Size Exclusion Chromatography (SEC), Light Scattering, Static Light Scattering

OMNISEC

OMNISEC

The world’s most advanced multi-detector GPC/SEC system

More details
Technology
Size Exclusion Chromatography (SEC)
Gel Permeation Chromatography
Measurement type
Molecular structure
Molecular size
Molecular weight