The 40th Annual Meeting of the Japan DDS Society Luncheon Seminar

Multifaceted Physical Property Evaluation and Automation Solutions in LNP Development and Manufacturing

We are pleased to announce that we will be holding a luncheon seminar titled ‘Multifaceted Physical Property Evaluation and Automation Solutions in LNP Development and Manufacturing’ at the 40th Annual Meeting of the Japan DDS Society.

About the Luncheon Seminar

Title: Multifaceted Physical Property Evaluation and Automation Solutions in LNP Development and Manufacturing
Speaker: Ryotaro Matsuo, Product Specialist, Malvern Panalytical

Lipid nanoparticles (LNPs) hold great potential in treating, curing, and preventing a variety of challenging conditions, from genetic disorders to cancer. These vectors enable efficient delivery of therapeutic drugs such as RNA. Unlike virus vector manufacturing, LNPs can be produced using a cell-free production process, allowing for rapid scale-up. However, due to the complexity of their structure, LNP therapy presents challenges in development and manufacturing analysis. Accurate measurement and careful control of various key characteristics are required to evaluate the stability of LNPs. In addition, guidance and information provision for product design, production process optimization, and release specifications are necessary.
Traditional methods used to characterize the properties of conventional therapies, such as monoclonal antibody therapy, often do not suit the complexity and pace of new LNP-based therapies. Therefore, there is an urgent need for analytical packages that combine cross-disciplinary and multifaceted evaluation methods to complement traditional techniques.
In this seminar, we will introduce analytical instruments (DLS/MADLS, NTA/PTA, ELS, SEC-SLS) used to evaluate key LNP factors such as size, polydispersity, concentration, surface charge, and therapeutic drug information, including measurement principles and examples. We will also introduce the newly developed Sample Assistant accessory for automation and unmanned operation, essential functions for analytical instruments. By using the Sample Assistant, the previously tedious sample exchange during DLS measurements becomes automated, improving device operating rates and enhancing operator productivity by freeing up time for other tasks.

How to Participate in the 40th Annual Meeting of the Japan DDS Society

• Date and Time:
  Luncheon Seminar: July 11, 2024 (Thursday) 12:30 – 13:30
  Annual Meeting: July 9 (Tuesday) – 11 (Thursday), 2024 *We will have a corporate exhibit during this period, so please visit us.
• Location: Tsukuba International Conference Center
• For details on participation in the annual meeting, please visit the annual meeting web page ▶Click here

Our Company’s Exhibit

At Malvern Panalytical, we offer a variety of analytical methods in LNP manufacturing and development, supporting multi-faceted analysis and proposing automation for labor-saving solutions.
At our corporate exhibit booth, you will be able to see the equipment explained in the luncheon seminar and the actual automated accessory for the Zetasizer’s sample exchange, the ‘Sample Assistant.’ Please visit our booth during the meeting.

NanoSight Pro

Zetasizer

Zetasizer Sample Assistant