MicroCal PEAQ-DSC
The MicroCal PEAQ-DSC system provides highly sensitive, easy-to-use microcalorimetry that helps reduce the time and cost associated with stability testing and comparability analysis. The MicroCal PEAQ-DSC is a manual instrument with a cleaning device, which can be upgraded to an automated version upon request.
Data generated by the MicroCal PEAQ-DSC provides critical guidance for biopharmaceutical development in protein engineering, (pre)formulation development, process development, manufacturing change control and biosimilarity and biocomparability studies. The integrated software streamlines workflows, facilitates non-subjective data analysis, performance qualification and compliance with 21 CFR Part 11 and Annex 11 regulations, all delivering high integrity data and driving productivity in biopharmaceutical research.
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Manuals
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Software
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Service and Support
MicroCal PEAQ-DSC instruments provide value to a wide range of applications, some of which are outlined below.
Protein Characterization
MicroCal PEAQ-DSC is a fundamental tool for characterizing proteins. Key questions such as below can all be answered in simple DSC experiments.
- Is my protein folded?
- In what conditions is my protein stable?
- Is the protein multi domain?
- Does my protein bind a ligand or cofactor?
Liposomes
Liposomes are used as model membrane systems and as potential drug delivery systems. ‘Structure Activity Relationships’ (SAR) of membrane components and drug uptake into a liposomes can be investigated monitoring shifts in the phase transition temperatures and enthalpies measured by DSC. Indeed, any material that forms micelles or other macromolecular structures can be studied using the technique.
Application note: Using DSC to characterize thermotropic phase transitions in lipid bilayer membranes: The basics of liposome sample preparation and DSC studies