Microcalorimeters are ultrasensitive calorimetry instruments,  that measure very small heat changes from chemical reactions. Microcalorimeters use small sample volumes, making it suitable for biomaterials such as proteins,  nucleic acids and lipids. 

Why is a microcalorimeter right for my application?

Microcalorimeters are used to study binding interactions between molecules, and conformational changes such as protein unfolding. Since microcalorimeters measure heat, microcalorimetry is considered a label-free technique. Also, microcalorimeters do not require proteins and other biomaterials to be captured or immobilized.

Detection of heat change by microcalorimeters is non-optical and does not rely on measurements of fluorescence, so microcalorimeters can be used with essentially any naturally occurring protein or biopolymer materials. Applications range from confirming intended binding targets in small molecule drug discovery to the development of stable biologic drugs.

Microcalorimeters include two types of instruments: Isothermal Titration Calorimetry (ITC)  and Differential Scanning Calorimetry (DSC).    

Malvern Panalytical microcalorimeters

We offer the MicroCal PEAQ-ITC and MicroCal PEAQ-DSC microcalorimeters. MicroCal microcalorimeters have been manufactured since the 1970s and are the leading provider of microcalorimeters for life sciences and drug discovery and development. MicroCal PEAQ-ITC and MicroCal PEAQ-DSC microcalorimeters are precision manufactured for sensitive heat detection, as well as ease-of-use and reliability. All MicroCal microcalorimeters are supplied with advanced instrument control and data analysis software.

MicroCal PEAQ-ITC

MicroCal PEAQ-ITC Automated

MicroCal PEAQ-DSC Automated

MicroCal PEAQ-DSC

MicroCal PEAQ-ITC MicroCal PEAQ-ITC Automated MicroCal PEAQ-DSC Automated MicroCal PEAQ-DSC

The Gold Standard for measuring affinity and stoichiometry

Fully automated, hands free ITC for increased productivity

Gold standard protein stability analysis for the regulated environment

Gold standard protein stability analysis for research applications

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Technology
Isothermal Titration Calorimetry (ITC)
Differential Scanning Calorimetry (DSC)
Sample throughput Up to - 12per 8h day Up to - 42per 24h day Up to - 50per 24h day Up to - 6per 8h day