Applications of molecular weight
Understanding molecular weight determination, absolute molecular weight measurement and other molecular parameters is key to controlling product performance in a wide variety of application areas including:
- Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs)
- Degradation and release rate of drug delivery polymers
- Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives
- Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives
- Strength, durability and toughness of plastics and other synthetic polymers
Static light scattering (SLS) enables absolute molecular weight determination directly in solution, without the need for column separation or external standards. Dynamic light scattering (DLS) complements SLS by providing hydrodynamic size data from the same sample. While DLS does not directly measure molecular weight, the hydrodynamic radius data it delivers can be used to estimate molecular weight using established empirical relationships.