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Molecular weight

Absolute molecular weight determination and measurement of molecular weight distribution.

Molecular weight

The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Applications of molecular weight

Understanding molecular weight determination, absolute molecular weight measurement and other molecular parameters is key to controlling product performance in a wide variety of application areas including:

  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs)
  • Degradation and release rate of drug delivery polymers
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives
  • Strength, durability and toughness of plastics and other synthetic polymers

Static light scattering (SLS) enables absolute molecular weight determination directly in solution, without the need for column separation or external standards. Dynamic light scattering (DLS) complements SLS by providing hydrodynamic size data from the same sample. While DLS does not directly measure molecular weight, the hydrodynamic radius data it delivers can be used to estimate molecular weight using established empirical relationships.

How our products compare

  • Zetasizer Advance Range

    Light Scattering for every application

    Zetasizer Advance Range

    Measurement type

    • Molecular size
    • Molecular weight

    Technology

    • Dynamic Light Scattering
    • Static Light Scattering
    • X-ray Diffraction (XRD)
    • Colloidal stability
    • Thermal stability
  • Zetasizer Core

    Next generation biophysical screening at scale

    Zetasizer Core

    Measurement type

    • Molecular size
    • Molecular weight

    Technology

    • Dynamic Light Scattering
    • Static Light Scattering
    • X-ray Diffraction (XRD)
    • Colloidal stability
    • Thermal stability
  • Empyrean Nano Edition

    Versatile X-ray scattering platform

    Empyrean Nano Edition

    Measurement type

    • Molecular size
    • Molecular weight

    Technology

    • Dynamic Light Scattering
    • Static Light Scattering
    • X-ray Diffraction (XRD)
    • Colloidal stability
    • Thermal stability