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Molecular weight

Absolute molecular weight determination and measurement of molecular weight distribution.

The molecular weight of proteins, synthetic and natural polymers is a direct indicator of product performance and activity.

Understanding molecular weight determination, absolute molecular weight measurement and other molecular parameters is key to controlling product performance in a wide variety of applications areas including:

  • Strength, durability and toughness of plastics and other synthetic polymers.
  • Degradation and release rate of drug delivery polymers.
  • Performance and mouth-feel of polysaccharides in foods e.g. maltodextrin and other starch derivatives.
  • Strength and quality of fillers and lubricants in pharmaceuticals and cosmaceuticals e.g. hyaluronic acid and cellulose derivatives.
  • Efficacy and aggregation state of proteins and biopharmaceuticals e.g. monoclonal antibodies (mAbs).

Malvern Panalytical’s advanced GPC/SEC detectors, which include low angle and right angle light scattering (LALS and RALS) and multi-angle light scattering (SEC-MALS), are designed to measure absolute molecular weight with unparalleled accuracy. The OMNISEC system offers a complete stand-alone solution to measure molecular weight, and the OMNISEC REVEAL detector module can be used to upgrade an existing GPC/SEC system. The SEC-MALS 20 can be added to either of these solutions to add further capabilities to the solution.

OMNISEC

OMNISEC

The world’s most advanced multi-detector GPC/SEC system

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Zetasizer Advance Range

Zetasizer Advance Range

Light Scattering for every application

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Empyrean Nano Edition

Empyrean Nano Edition

Versatile X-ray scattering platform

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Measurement type
Molecular structure
Molecular size
Molecular weight
Technology
Gel Permeation Chromatography
Size Exclusion Chromatography (SEC)
Dynamic Light Scattering
Static Light Scattering
X-ray Diffraction (XRD)