Addendum to NanoSight NS300 User Manual (English)
Version number: ADD0112-02-EN
NanoSight NS300
The Malvern Panalytical NanoSight NS300 Instrument provides an easy-to-use, reproducible platform for nanoparticle characterization.
The NS300 allows rapid, automated analysis of the size distribution and concentration of all types of nanoparticles from 0.01 - 1 µm* in diameter, depending on the instrument configuration and sample type.
With the ability to be supplied with interchangeable laser modules and the introduction of a motorized 6 place filter wheel means different fluorescent labels can be analyzed. Sample temperature is fully programmable through the Nanoparticle Tracking Analysis (NTA) software.
*sample and system configuration dependent
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User manuals
NanoSight NS300 user manual (English)
Version number: MAN0541-03-EN
NanoSight Sample Assistant Basic Guide (English)
Version number: MAN0596-02-EN
NanoSight NS300 user manual (English)
Version number: MAN0516-08-EN-00
NanoSight Syringe pump user manual (English)
Version number: MAN0534-03-EN-00
NanoSight NTA software installation manual (English)
Version number: MAN0515-02-EN-00
NanoSight NS300 NTA Software guide (English)
Version number: MAN0545-01-EN-00
NanoSight NTA 2.3 Analytical Software user manual (English)
Version number: MAN0514-01-EN-00
NanoSight NTA 2.3 software quick start guide (English)
Version number: MAN0520-01-EN-00
Software downloads
3.44
Capture
• USB camera support.
Other
• Improved logging. Instrument log files will no longer be overwritten at the start of each day.
• Improved handling of corrupt/unreadable video files.
• New script command for automated/unattended data export.
• Resolved HASP issues in Windows 10 (Version 2004)
3.40
Improvements including:
- USB camera support
- Improved logging
- Improved handling of video files
- New script commands for data export
3.30
Improvements including:
- New SOP pages
- CFR
3.20
Improved Automation
- Auto-setup, auto-level, focus-level, and auto-focus script commands available
- Script command to change experiment filename
- Make background script commands added
- Changes to continuous flow SOP scripts to ensure smooth flow
Exports
- Laser color added to nanolog.csv and other outputs
Interface changes
- Run button on Recent Measurements page
- User direction messages for capture and process settings improved
- User Positions 1 and 2 removed
Additional features
- Optional CFR feature available – audited operation, secure login, data integrity checking, user level program configuration
- CFR feature can be enabled by adding feature code to CFR security dongle
- The CFR feature is available as a chargeable upgrade – Part No. PSS0054 for new builds, Part No. NTA4165 as an upgrade for customers running NTA 3.2 software
Other
- Extended camera log for diagnostic purposes, can revert to daily usage via nano.ini
3.10-I2
Improvements and Features
- Concentration measurement upgrade option for NS500 and single and multi-laser NS300
Improved Automation
- Automatic focus available for NS300 and NS500
- Automatic camera level for all instruments
Data Display and Manipulation
- Flexible data overlays for line graphs and scatter plots
- CSV and PDF export options for overlaid data
- Ability to report concentrations between specific size limits
- Option to ‘exclude’ regions of particles from the scatter plot
- Updated display for zeta plots
Interface changes
- Quick access to recent experiments through dedicated tabbed window
- Experiments display overlaid graphs and scatterplots on load
- Improved flexibility and usability for graph settings
- Filter wheel has its own hardware tab, with customisable buttons
- Procedure guide for electrode air removal
- Warnings to remind user of essential hardware checks/maintenance
Additional improvements
- Refined camera levels to give more suitable settings for brighter particles
- Refined detection threshold range
- Speed optimised size distribution algorithm runs up to 20 times faster
- Refined focus and stage controls for ease-of-use
- Option to correct viscosity and dilution after making a measurement
- Improved hardware auto-detection and reconnection menus
3.10-I1
Improvements and Features
- Concentration measurement upgrade option for NS500 and single and multi-laser NS300
Improved Automation
- Automatic focus available for NS300 and NS500
- Automatic camera level for all instruments
Data Display and Manipulation
- Flexible data overlays for line graphs and scatter plots
- CSV and PDF export options for overlaid data
- Ability to report concentrations between specific size limits
- Option to ‘exclude’ regions of particles from the scatter plot
- Updated display for zeta plots
Interface changes
- Quick access to recent experiments through dedicated tabbed window
- Experiments display overlaid graphs and scatterplots on load
- Improved flexibility and usability for graph settings
- Filter wheel has its own hardware tab, with customisable buttons
- Procedure guide for electrode air removal
- Warnings to remind user of essential hardware checks/maintenance
Additional improvements
- Refined camera levels to give more suitable settings for brighter particles
- Refined detection threshold range
- Speed optimised size distribution algorithm runs up to 20 times faster
- Refined focus and stage controls for ease-of-use
- Option to correct viscosity and dilution after making a measurement
- Improved hardware auto-detection and reconnection menus
3.0
Improvements and Features
- Redesigned interface, focusing around repeat measurements
- Improved particle size distribution algorithm
- Automatic, integrated hardware detection and communication
- Increased compatibility with networked computers
- Easy setup with new installer package
- Additional features
- New file system with less files per experiment
- Improved particle detection and tracking
- Improved vibration correction
- Settings stored in the registry rather than .ini file
1.2
- Maintenance including improved tracking algorithms
See SUN for more details.
1.1
- Project export and import
- General workflow and existing feature improvements
- Improved robustness for fluorescence measurements
- Minor bug fixes
See SUN for more details.
1.0
NanoSight Software Activation Tool v1
1.0
NS Xplorer is the software for the NS Pro instrument
- 1st Release
Accessories
NanoSight Sample Assistant
Sample storage and walk-away NTA measurements
The NanoSight Sample Assistant is a 96-well plate-based autosampler accessory with a bespoke software suite allowing for walk-away NTA measurements.
NanoSight syringe pump
The Malvern Panalytical NanoSight syringe pump is available for all Malvern Panalytical NanoSight systems, enabling analysis in constant flow for improved sample statistics and measurement of photo-bleaching fluorescent samples.
Events and training
All events
Best Practices for Nanoparticle Tracking Analysis
- Products:
- NanoSight NS300, NanoSight range
- Technology:
- Nanoparticle Tracking Analysis, Dynamic Light Scattering
- Measurement type:
- Particle size, Particle concentration
Tracking the size and concentration of extracellular vesicles
- Products:
- NanoSight NS300
- Technology:
- Nanoparticle Tracking Analysis
- Industry:
- Biologics, Pharmaceutical
Top tips for characterizing lipid nanoparticles: Vector analytics masterclass 1 of 6
- Products:
- Zetasizer Advance Range, MicroCal DSC range, NanoSight NS300
- Technology:
- Dynamic Light Scattering, Electrophoretic Light Scattering, Differential Scanning Calorimetry (DSC)
Finding fit-for-purpose analytics: AAV characterization and formulation development
- Products:
- Zetasizer Ultra, OMNISEC system, MicroCal PEAQ-DSC, NanoSight NS300
- Technology:
- Nanoparticle Tracking Analysis, Dynamic Light Scattering, Size Exclusion Chromatography (SEC), Differential Scanning Calorimetry (DSC)
- Industry:
- Biologics
Service and Support
Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.
When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.
Help Desk
- Telephone and email support.
- Operators who take responsibility for your call and ensure your query is answered.
Training
- User training events
Software downloads
Malvern Panalytical's service options- choose the right plan for you:
Malvern Panalytical Platinum Plan
For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.
Malvern Panalytical Gold Plan
Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.
Malvern Panalytical Bronze Visit
For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.
| Platinum Plan | Gold Plan | Bronze Visit | |
|---|---|---|---|
| Annual PM/PV Test | yes | yes | no |
| Telephone / Email Support | yes | yes | no |
| Priority Response | yes | yes | no |
| Emergency Breakdown visits* | yes | yes | no |
| Parts Included | yes | no | no |
| Technical & Software Support | yes | yes | yes |
| IQ/OQ (Pharma)*** | yes | yes | yes |
*including labour & travel costs ***available at an additional cost