The Zetasizer Nano S is the system of choice where the highest sensitivity and widest size range is required. It has the same sizing capability as the top of the range Zetasizer Nano ZS.

It is a particle size analyzer for the enhanced detection of aggregates, measurement of small or dilute samples, or samples at high concentration, plus a molecular weight analyzer for molecular size and molecular weight measurement.

Static light scattering measurements enable determination of the second virial coefficient for macromolecule solubility tests.

  • Size measurement from 0.3nm (diameter) to 10 microns using patented NIBS (Non-Invasive Back Scatter) technology.
  • Molecular weight measurement down to 980Da.
  • Second virial coefficient measurement for solubility.
  • Automated temperature trend measurements.
  • Sample concentrations from 0.1ppm to 40%w/v.
  • Protein size measurement as dilute as 0.1mg/mL (Lysozyme).
  • A Quality Factor gives confidence in the data.
  • The Expert advice report gives help to improve sample preparation or the measurement procedure.
  • 21CFR part 11 software option enables compliance with ER/ES.
  • Research software option gives access to further features and analysis algorithms for the light scattering specialist.
  • Automation of measurements using an autotitrator option.
  • Flow mode capability to enable use as a GPC / SEC detector.
  • Alternative laser, 50mW at 532nm for samples incompatible with the standard 633nm laser fitted.
  • Optical filter option to improve measurements with fluorescent sample.
  • Temperature range extension option to 120ºC.
  • Systems can be upgraded to add zeta potential at a later date.

The Zetasizer Nano S incorporates 2 techniques in a single compact unit, and has a range of options and accessories to optimize and simplify the measurement of different sample types.

Dynamic Light Scattering is used to measure particle size and molecule size. This technique measures the diffusion of particles moving under Brownian motion, and converts this to size and a size distribution using the Stokes-Einstein relationship. Non-Invasive Back Scatter technology (NIBS) is incorporated to give the highest sensitivity simultaneously with the highest dynamic size and concentration range.

Static Light Scattering is used to determine the molecular weight of proteins and polymers. In this technique, the scattering intensity of a number of concentrations of the sample is measured, and used to construct a Debye plot. From this the average molecular weight and second virial coefficient can be calculated.
This measurement is very demanding on the sensitivity and stability of the whole system, and means that every element of the design has been optimised to ensure accuracy and repeatability

Software
The software is designed to be versatile and rich in features without compromising ease of use. Standard Operating Procedures (SOP) simplify routine measurements, a quality factor gives a single place to look for the success of a measurement, and expert advice is given to assist with data interpretation.

Options
The MPT-2 Autotitrator enables the study the effect of changes in pH, conductivity, or any additive to be automated.
A range of disposable and reusable cells are available to optimise the measurement in terms of sample volume, concentration and for flow measurement.

Other options include filters to improve the measurement of fluorescent samples, a temperature range extension to 120ºC and a viscometer to determine the sample viscosity to the accuracy required for the techniques used.

Particle size and molecular size

Measurement range:
0.3nm – 10.0 microns* (diameter)
Measurement principle:
Dynamic Light Scattering
Minimum sample volume:
12µL
Accuracy:
Better than +/-2% on NIST traceable latex standards
Precision / Repeatability:
Better than +/-2% on NIST traceable latex standards
Sensitivity:
0.1mg/mL (Lysozyme)

Molecular weight

Measurement range:
980Da – 20M Da*
Measurement principle:
Static Light Scattering using Debye plot
Minimum sample volume:
12µL (3-5 sample concentrations required)
Accuracy:
+/- 10% typical
Precision / Repeatability:
Better than +/-2% on NIST traceable latex standards
Temperature control range:
0°C - 90°C +/-0.1**, 120ºC option
Light source:
He-Ne laser 633nm, Max 4mW
Laser safety:
Class 1
Power:
100VA

Weight and dimensions

Dimensions (W, D, H):
320mm, 600mm, 260mm (W,D,H)
Weight:
21 (kg)

Operating environment

Operating temperature (°C):
10°C – 35°C
Humidity:
35% - 80% non-condensing

Notes

Patents:
The Zetasizer Nano range is protected by the following patents: Non-Invasive Back Scatter (NIBS) EP884580, US6016195, JP11051843 High and Low Frequency Electrophoreses (M3) EP1154266, US7217350, JP04727064 Light Scattering Measurements using Simultaneous Detection EP2235501, CN102066901, JP2011523451, US20090251696 Surface Potential Determination in a Dip Cell WO2012172330
A range of accessories are available to make life easier, or to add capability to the system

Zetasizer Nano S

Accessories

NanoSampler

Automated particle size measurement for the Zetasizer Nano

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The Zetasizer NanoSampler is a sample delivery system that ensures highly precise and reproducible automated loading of samples into your Zetasizer Nano. The NanoSampler adds automation and unattended operation in a versatile, compact package, maximising the productivity of your Zetasizer Nano. While the benefits of automated operation are useful for all users, the NanoSampler is ideally suited for laboratories where a large number of measurements are required and reproducibility or multi-variate studies are important.

More information

MPT-2

Simplify pH, conductivity and additive titrations on your Zetasizer Nano

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A cost effective accessory designed to automate the measurement of size and zeta potential as a function of pH, conductivity or any soluble additive.

More information

SV-10 viscometer

Viscosity measurement with speed, simplicity and accuracy.

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The SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.

More information

Cell and cuvette options

Quartz flow cell (ZEN0023)

Add flow capability for size measurements to the Zetasizer.

  • Measure size and intensity with MPT-2 autotitrator.
  • Connect to an SEC system to use as a DLS detector.
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12mm Glass cell (PCS1115)

Glass cuvette for use with the dip cell.

  • For size and zeta potential measurements using the ‘dip’ cell.
  • Compatible with aqueous and non-aqueous solvents and dispersants.
Visit store to buy now

12mm Square Polystyrene Cuvettes (DTS0012)

Disposable polystyrene cuvettes.

  • 100 disposable cells complete with 100 stoppers to avoid cross contamination.
  • For size measurements using aqueous dispersants.
  • Compatible with zeta potential measurements using the dip cell.
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12mm square glass cell (PCS8501)

Glass cuvette for batch measurements.

  • For size and molecular weight measurements.
  • Compatible with aqueous and non-aqueous solvents and dispersants.
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Disposable Solvent Resistant Micro Cuvette (ZEN0040)

Disposable plastic micro cuvette, for size measurement at 173° (NIBS) optics only.

  • 100 x 40µL cuvettes with 100 caps to avoid cross contamination.
  • Compatible with aqueous samples and a range of other solvents: Acetone, Benzaldehyde, Butanone, Dioxane, DMF, Ethyl acetate, Isopropanol, plus various acids and bases.
Visit store to buy now

Low-volume quartz batch cuvette (ZEN2112)

Low-volume quartz batch cuvette for size and molecular weight measurements.

  • Compatible with size and molecular weight measurements with aqueous and non-aqueous solvents and dispersants.
  • Minimum sample volume 12 microliters.
  • Maximum volume 45 microliters.
Visit store to buy now

Protect your investment and ensure optimized performance at all times with Malvern’s service plans.

When you purchase a Malvern product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern will provide the support for your business.

Help Desk

Training

Software downloads

Malvern’s service options- choose the right plan for you:

Malvern Platinum Plan

For laboratories where maximizing instrument up-time is critical to its daily performance. Our highest level of response and the 'all inclusive' price plan takes care of those unexpected repair bills should the unfortunate occur.

Malvern Gold Plan

Enhance your laboratory productivity by maintaining instrument efficiency. Still receive that priority response, combined with specialist technical and software support, we'll keep your instrument performance on track to deliver.

Malvern Bronze Visit

For laboratories looking to optimize instrument performance, regular preventative maintenance is essential.

Platinum PlanGold PlanBronze Visit
Annual PM/PV Test
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Telephone / Email Support
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Priority Response
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Emergency Breakdown visits*
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Parts Included
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E-Learning**
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Technical & Software Support
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IQ/OQ (Pharma)***
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*including labour & travel costs** Platinum 2 places per contract term, Gold 1 place per contract term***available at an additional cost