Zetasizer Pro

Features and benefits

Even novice users will produce the highest-quality measurements, thanks to the intuitive interface and the deep learning empowered data quality advice system that highlights issues and provides advice on how to overcome them.  

• Dynamic Light Scattering (DLS) measures particle and molecule size, from below 1 nm to 10 µm
• Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate
• Non-Invasive Back-Scatter (NIBS) optics for versatile, high sensitivity, particle and molecular size measurements
• M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements
  
• ZS Xplorer software suite for simple and flexible method set-up and data analysis
• Adaptive Correlation for faster, more reproducible sizing measurements with less sample preparation
• Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results
• Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity.  Also includes polarization filters for DDLS measurements
• The optional MPT-3 Auto titrator enables study of the effect of changes in pH
• A range of disposable and reusable cells are available to optimize the measurement in terms of sample volume and concentration

Key applications

The Malvern Panalytical Zetasizer Pro can be used in many industry applications, including:

Academia

The Zetasizer is an essential analytical tool for many academic laboratories worldwide, finding use in all applications where particle or molecular size and zeta potential analysis is required. The breadth of applications covered by Zetasizer systems, coupled with tens of thousands of scientific citations, have earned these instruments a central space in many scientific faculties. 

Bioscience

Variations in molecule concentration, external temperature, level of agitation and time all impact the stability of biological molecules. Instabilities mainly result in denaturation and aggregation of the molecule through which they can lose their biological function , elicit an immune response and consequently limit its therapeutic viability. Factors affecting therapeutic efficacy and immunogenicity therefore need to be monitored throughout the development pipeline especially at early stages to de-risk the biological drug molecule and limit late-stage failures. The Zetasizer range provides high quality, stability indicating data for biological drug molecules in a short time frame, enabling this measurement to be implemented throughout the development pipeline.   

Food and drink 

Zetasizer systems are used to analyze particle size and zeta potential to improve the appearance and taste of foods, drinks and flavorings, and optimize dispersion and emulsion stability to extend product shelf life and improve product performance.

Nanomaterials

Zetasizer measurements of nanoparticle size distribution, dispersion properties, stability and propensity to aggregate are crucial to the design of new nanomaterials. The very large surface area of such materials may result in novel physical and chemical properties, such as increased catalytic activity, improved solubility or unexpected optical or toxicological behaviour.

Paints, inks and coatings

Paint, ink and coating formulations must be stable to keep them in an optimum state over time without change or aggregation. Particle size and zeta potential, measured by the Zetasizer instruments, play important roles in determining a product’s properties, such as dispersibility, color, strength, finish, durability and shelf life.

Pharmaceuticals

The correct particle size and zeta potential can help ensure the production of effective therapeutics, delivered safely. Zetasizer systems are used to characterize the stability and quality of dispersions, emulsions and creams, reducing formulation time and speeding new products to market.

Specification

Particle size and molecular size

Measurement principle:

Dynamic light scattering (Non- Invasive Back-Scatter - NIBS)

Dynamic light scattering (13°, 173°)

Measurement angle:

173°, 13° ¹

Measurement range:

Diameter: 0.3 nm - 10 μm ²

Minimum sample volume:

12 μL

Concentration range:

Minimum sample concentration ³:  

NIBS (173°): 

0.1 mg/mL 

 

Forward angle (13°): 

10 mg/mL 

 

Side angle (90°): 

N/A

 

MADLS: 

N/A

 

Maximum sample concentration ⁴ ⁵:  

40% w/v 

Zeta potential

Measurement principle:

Mixed-mode measurement, phase analysis light scattering (M3-PALS)

Size range:

3.8 nm – 100 μm (diameter) ²

Minimum sample volume:

20 μL ⁶

Concentration range:

10 mg/mL ³ - 40% w/v ⁴ ⁵

Sample conductivity range:

Maximum: 260 mS/cm 

Accuracy: ± 10%

System

Detector:

Avalanche photodiode

Temperature control range:

0°C - 120°C ⁷

Dimensions (W, D, H):

322 mm x 565 mm x 245 mm

Weight:

19 kg

Power:

AC 100-240 V, 50-60 Hz, 4.0 A

Power consumption:

Max. 100 W, 45 W typical

Ambient conditions:

+10°C to +35°C (+50°F to +95°F) 35% - 80% RH (non-condensing)

Interface:

USB 2.0 or higher

Notes

:

1. Water as sample dispersant; 

2. Peak mode range (diameter) 0.6 nm - 10 μm; sample & sample preparation dependent; 

3. Measured using 15 kDa protein; 

4. Sample-dependent; 

5. Measured using bile acid; 

6. Using diffusion barrier method; 

7. Temperature accuracy 0.1°C at 25°C, 0.2°C at 0°C, 0.5°C at 90°C, 2.5°C at 120°C

Accessories

Zetasizer Pro

Accessories

SV-10 viscometer

Viscosity measurement with speed, simplicity and accuracy.

The SV-10 measures viscosity with the accuracy required for dynamic light scattering, for the conversion of diffusion speed to size, and electrophoretic mobility to zeta potential, in an extremely simple and rapid system.

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Cell & cuvette options

Disposable folded capillary cell (DTS1070)

Eliminate sample cross contamination between zeta potential measurements using a completely disposable cell.

The zeta potential of colloids and molecules is extremely sensitive to contamination from components of a previous sample used in a measurement cell. The use of a disposable cell completely eliminates this potential contamination issue.

The folded capillary cell provides the benefits of the accuracy of measurement of a capillary cell with the ease of use of a disposable cell.

Although, disposable, including the electrodes, for low conductivity samples each cell can be used for hundreds of measurements if required.

The cell can be used with the autotitrator, where multiple measurements are routinely done over a wide pH range.

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Universal 'dip' cell kit

Reusable solvent resistant cell.

The dip cell is used for the measurement of zeta potential of samples in aqueous and non-aqueous dispersants, and is designed to be cleaned and reused. It is for batch measurements using standard polystyrene or glass cuvettes.

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High concentration zeta potential cell kit

Save time and effort by measuring zeta potential with little or no dilution.

The high concentration cell enables the measurement of the zeta potential of samples with little or no dilution in any Zetasizer Nano system that measures zeta potential.

The cell has a flow configuration so can be used for stop-flow size and zeta potential measurements using an MPT-2 autotitrator as well as batch measurements.

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MPT-3 Autotitrator

Automate your pH titrations

The MPT-3 is a cost effective accessory for your Zetasizer Pro and Zetasizer Ultra, designed to automate your Zeta and/or Size vs. pH titrations, helping you understand how your materials behave as a function of pH.   

The zeta potential and/or size of your materials with pH changes can be critical in understanding: 

• Material stability
• Agglomeration
• Flocculation 
• Point of net zero charge (isoelectric point)
• Storage conditions

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Support

Protect your investment and ensure optimized performance at all times with Malvern Panalytical's service plans.

When you purchase a Malvern Panalytical product we understand that this is just the first stage of a working relationship that will last for the lifetime of the instrument. Depending on your needs, Malvern Panalytical will provide the support for your business.

Help Desk

• Telephone and email support.
• Operators who take responsibility for your call and ensure your query is answered.

Training

• User training events

Software downloads

• A simple mechanism for receiving updates and new features

Malvern Panalytical's service options- choose the right plan for you:

*including labour & travel costs***available at an additional cost