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Trust Every Result with Zetasizer Advance. Accelerate decisions with confidence using the Zetasizer Advance, combining industry leading particle characterisation, intelligent automation and compliant data integrity in one powerful platform.
Building on the success of the market-leading Zetasizer Nano, it delivers precise particle size, zeta potential, and molecular weight analysis with cutting-edge technologies like Adaptive Correlation, M3-PALS, and smart data quality guidance. Flexible and upgradeable on-site, it adapts as your research or production needs evolve.
For protein researchers, early access to characterization data can be a challenge, due to low sample volumes. This is easily overcome using the Zetasizer Lab with the capillary cell to confirm that samples meet quality requirements and that production and purification processes are optimized.
Monitoring viral concentration is important during development and production optimization. By using the Multi-Angle DLS (MADLS) based particle concentration measurement in the Zetasizer Ultra, both the size distribution and titer of the virus can be measured within a few minutes.
Photoluminescent C-dots are considered safer alternatives to quantum dots. Measuring fluorescent samples by DLS can be challenging due to additional photons emitted by the fluorophore. Available with NIBS on Zetasizer Pro, a filter removes this interference to provide accurate and reliable data.
The strength of ceramics is linked to particle size, and the Zetasizer is ideally placed to measure this. Al₂O₃ samples are often made of differently-sized particles which can easily be identified using MADLS. In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single angle DLS measurement.
Titanium dioxide use is wide-ranging. When used in paints or inks, agglomerate or aggregate formation can diminish product performance. The Zetasizer Pro Blue Label, used alongside the MPT‑3 Autotitrator, characterizes the impact of salt concentration on the stability of TiO₂ and identifies the most stable pH region.
Sizing of colloidal silica is a critical requirement. This is easily and reproducibly measured using the Zetasizer.
Comprehensive characterization for modern particle and protein research. Measure key properties including particle size, zeta potential, molecular weight, and concentration.
Each of the three models in the range offers particle size, particle charge (zeta potential) and molecular weight analysis. In addition, each benefits from advances including Adaptive Correlation, M3-PALS zeta potential analysis, constant current zeta mode and our deep learning-based data quality advice system.
Our most advanced system for the measurement of particle and molecular size, particle charge and concentration.
The Zetasizer Pro is your go-to instrument to measure a wide range of sample types and concentrations.
The Zetasizer Lab is an entry-level system that employs classical 90° sizing with advanced features.
Ultra model only
Zeta potential size range
Ultra & Lab models only
Ensure system access and records are secure, consistent, and easy to review for 21 CFR Part 11 with OmniTrust - our compliance solution for regulated environments.
Regulated environmentOmniTrust is Malvern Panalytical’s multi-instrument solution for regulatory compliance and data integrity.
OmniTrust gives you peace of mind by providing robust regulatory compliance and data integrity, reducing the administrative burden on users. It streamlines workflows and is designed to be user-friendly, making it easy to implement and use on a daily basis.
| Detector | Avalanche Photodiode | |
|---|---|---|
| Laser safety | He-Ne (633 nm); 10 mW max.
4mW HeNe available in blue range |
|
| Temperature control range |
|
|
| Dimensions (W, D, H) | 322 mm x 565 mm x 245 mm | |
| Weight | 19 kg | |
| Power | AC 100-240 V, 50-60 Hz, 4.0 A | |
| Power consumption | Max 100 W, Typical 45 W | |
| Ambient conditions | +10°C to +35°C, 35 to 80% RH (Non-condensing) | |
| Interface | USB 2.0 or higher |
| Measurement principle | Non-Invasive Back Scatter (NIBS) Dynamic Light Scattering
Dynamic Light Scattering (90° and 13°)
Multi-Angle Dynamic Light Scattering (MADLS) (Ultra model only)
|
|---|---|
| Measurement angle | Ultra: 173°, 13°, 90°
Pro: 173°, 13° Lab: 90°, 13° |
| Measurement range | 0.3 nm - 15 μm
15 μm is available on 90-degree-capable systems using a low-volume capillary cell and our extended-range analysis; otherwise, the range is 10 μm.
|
| Minimum sample volume | 1 μL using Low Volume Capillary Sizing Cell on 90-degree systems; otherwise, 12 μL |
| Accuracy | Better than+/- 2% (sample dependent) |
| Reproducibility | <1% (sample dependent) |
| Minimum sample concentration | 0.1 mg/mL 15 kDa Protein
Blue variants: 0.2 mg/mL 15 kDa Protein
MADLS: 0.1 mg/ml 15 kDa Protein |
| Maximum sample concentration | 50% w/v |
| Features | In-built Filter Wheel (VV, VH & Fluorescence): selectable in the method, fully traceable and protected from misalignment, contamination and misuse)
|
| Measurement principle | MADLS - Particle Concentration (Mie)
(Ultra Red system only)
|
|---|---|
| Concentration range | 1 × 10^8 to 1 × 10^12 particles/mL
(Ultra Red system only) |
| Calibration type | Single point system calibration only
(Ultra Red system only) |
| Accuracy | +/-10%
(Ultra Red system only) |
| Repeatability | +/- 5%
(Ultra Red system only) |
| Measurement principle | Mixed-Mode Measurement phase analysis light scattering (M3-PALS) |
|---|---|
| Size range | 3.8 nm – 100 μm |
| Minimum sample volume | 20 μL using patented diffusion barrier technique |
| Concentration range | 1 mg/mL to 70% w/v
(Systems fitted with a 10 mW laser; sample-dependent; measured using 15 kDa protein)
|
| Sample conductivity range | Maximum: 260 mS/cm |
| Accuracy | <10% (sample dependent) |
| Repeatability | <3% (sample dependent) |
| Molecular weight range | 300 Da – 20 mDa |
|---|---|
| Measurement principle | Static Light Scattering with Debye Plo |
| Accuracy | +/- 10% |
| International Standards Organization | ISO22412:2025
ISO13099-2:2025 |
|---|---|
| US Pharmacopoeia (USP) | 430 – Particle Size Analysis by Dynamic Light Scattering
432 – Determination of Zeta Potential by Electrophoretic Light Scattering
729 – Globule Size Distribution in Lipid Injectable Emulsions
1153 – Drug Products Containing Nanomaterials
1154 – Liposome Drug Products
1430 – Analytical Methodologies Based on Scattering Phenomena – General |
| ASTM | D4001
E2490
E2865
E3247 |
Enabling round-the-clock sample analysis: load up to 120 samples and walk away.
AccessoriesSignificantly improve your system utilization with the Sample Assistant – a new accessory for every Zetasizer Advance system. It frees the operator from manually changing samples.
The result? The same great data quality and versatility you expect from your Zetasizer Advance with even greater efficiency.
Choose from a range of accessories designed to expand capability, including system enhancements and a variety of cells and cuvettes.
Empowering scientists, one automated test at a time
Viscosity measurement with speed, simplicity and accuracy.
Automate your pH titrations
Eliminate sample cross contamination between zeta potential measurements using a completely disposable cell.
Reusable solvent resistant cell.
Save time and effort by measuring zeta potential with little or no dilution.
Glass cuvette for use with dip cell
Glass cuvette for batch measurements
Disposable polystyrene cuvettes
Low-volume quartz batch cuvette for size and molecular weight measurements.
Disposable plastic micro cuvette, for size measurement at 173° (NIBS) optics only
Proven in laboratories worldwide through customer experience and supported by thousands of scientific publications and citations.
The world’s most trusted light scattering system
High performance, versatile and robust
Classic side scatter particle size and zeta potential analyzer with enhanced capabilities
Accelerate decisions with confidence using the Zetasizer Advance, combining industry leading particle characterisation, intelligent automation and compliant data integrity in one powerful platform.
Trusted data. Faster workflows. Lower risk. Better outcomes.
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