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When data drives your decision there’s no room for guesswork. Zetasizer Advance Ultra delivers high-resolution particle size, concentration, zeta potential and molecular weight measurements — with the speed and precision needed to keep your projects moving. Built for scientists who need accuracy, sensitivity, and reliability in every run.
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When accuracy, clarity, and trust in your data matter, Zetasizer Ultra delivers. See how it can transform your workflow.
One platform, three critical answers : size, concentration, and zeta potential (Zetasizer Ultra also measures molecular weight).
Adaptive Correlation tailors each run to your sample’s behavior, reducing noise and delivering accurate data up to three times faster than traditional DLS.
ZS Xplorer software guides you through every step of analysis, to ensure high-quality data – even when the user isn’t a light scattering expert.
Machine learning-powered analysis detects data quality issues and gives clear, actionable advice - so you always get the best data from every sample.
Patented multi-angle DLS ( MADLS ) technology delivers 2:1 resolution size and concentration in minutes.
Pair with Zetasizer Sample Assistant to automate your measurements and increase system usage threefold.
Low volume sizing cell delivers accurate data from just 1 µL — ideal for scarce or high-value materials.
Sample options: From complex biological samples (like proteins and viruses) to ceramics and carbon dots, the Ultra handles it all.
Like other Zetasizer Advance systems, the Ultra pairs seamlessly with Sample Assistant for automation and OmniTrust for data integrity. That’s accuracy, automation and integrity, all in one workflow, so you can move projects forward with confidence.
You’ll see multimodal samples resolved with precision, with every measurement automatically optimized by Adaptive Correlation and high-resolution results delivered by our patented multi-angle dynamic light scattering (MADLS) technology.
When samples are unstable, polydisperse, or just plain difficult, other dynamic light scattering systems struggle. Zetasizer Ultra cuts through the noise to give you clear, high-resolution data, fast.
Zetasizer Ultra provides rapid, reliable characterization of lipid nanoparticles and viral vectors. Measure particle size, concentration, polydispersity, and zeta potential to assess stability, yield, and surface charge across formulation development and manufacturing workflows to refine processes and ensure batch-to-batch reproducibility.
Speed up analysis of viruses with fast size and concentration measurements. MADLS® technology enables simultaneous size and concentration measurement, determining viral titer and distribution in minutes. Monitoring these key parameters with Zetasizer Ultra helps you optimize processes, maintain quality, and reduce development time.
The strength of ceramics is linked to particle size, and the Zetasizer Ultra is ideally placed to measure this. Al2O3 samples are often made of differently-sized particles which can easily be identified using MADLS. In this 0.1% w/v sample, the two particle size populations would not be distinguishable with a single-angle DLS measurement.
The Zetasizer is an essential analytical tool for many academic laboratories worldwide, finding use in all applications where particle or molecular size and zeta potential analysis is required. The breadth of applications covered by Zetasizer systems, coupled with tens of thousands of scientific citations, have earned these instruments a central space in many scientific faculties.
Variations in molecule concentration, external temperature, level of agitation, and time all impact the stability of biological molecules. Instabilities mainly result in denaturation and aggregation of the molecule, through which they can lose their biological function, elicit an immune response, and consequently limit their therapeutic viability. Factors affecting therapeutic efficacy and immunogenicity, therefore, need to be monitored throughout the development pipeline, especially at early stages, to de-risk the biological drug molecule and limit late-stage failures. The Zetasizer range provides high-quality, stability-indicating data for biological drug molecules in a short time frame, enabling this measurement to be implemented throughout the development pipeline.
Zetasizer systems are used to analyze particle size and zeta potential to improve the appearance and taste of foods, drinks and flavorings, and optimize dispersion and emulsion stability to extend product shelf life and improve product performance.
Zetasizer measurements of nanoparticle size distribution, dispersion properties, stability and propensity to aggregate are crucial to the design of new nanomaterials. The very large surface area of such materials may result in novel physical and chemical properties, such as increased catalytic activity, improved solubility or unexpected optical or toxicological behavior.
Paint, ink and coating formulations must be stable to keep them in an optimum state over time without change or aggregation. Particle size and zeta potential, measured by the Zetasizer instruments, play important roles in determining a product’s properties, such as dispersibility, color, strength, finish, durability and shelf life.
The correct particle size and zeta potential can help ensure the production of effective therapeutics, delivered safely. Zetasizer systems are used to characterize the stability and quality of dispersions, emulsions and creams, reducing formulation time and speeding new products to market.
Ensure system access and records are secure, consistent, and easy to review for 21 CFR Part 11 with OmniTrust - our compliance solution for regulated environments.
Regulated environmentOmniTrust is Malvern Panalytical’s multi-instrument solution for regulatory compliance and data integrity.
OmniTrust gives you peace of mind by providing robust regulatory compliance and data integrity, reducing the administrative burden on users. It streamlines workflows and is designed to be user-friendly, making it easy to implement and use on a daily basis.
Proven in laboratories worldwide through customer experience and supported by thousands of scientific publications and citations.
Malvern Panalytical instruments are built to last and good maintenance and care ensure continued peak performance for many years to come.
SupportClick the links below to learn more about our support and aftercare options:
| Measurement principle | Non-Invasive Back Scatter (NIBS) Dynamic Light Scattering
Dynamic Light Scattering (90° and 13°)
Multi-Angle Dynamic Light Scattering (MADLS)
|
|---|---|
| Measurement angle | 173°, 13°, 90° |
| Measurement range | 0.3 nm - 15 μm 2 |
| Minimum sample volume | 3 μL |
| Concentration range | Minimum sample concentration:
Blue Label: 0.2 mg/mL 15 kDa Protein
Red Label: 0.1 mg/mL 15 kDa Protein
MADLS:
0.1 mg/ml 15 kDa Protein
MADLS Particle Concentration Enabled?
Blue Label: No
Red Label: Yes
Maximum sample concentration(3):
40% w/v
|
| Measurement principle | Mixed-Mode Measurement phase analysis light scattering (M3-PALS) |
|---|---|
| Size range | 3.8 nm – 100 μm |
| Minimum sample volume | 20 μL 4 |
| Concentration range | Red Label: 1 mg/mL 5 to 40% w/v 6
Blue Label: 10 mg/mL 5 to 40% w/v 6 |
| Sample conductivity range | Maximum: 260 mS/cm |
| Molecular weight range | 300 Da – 20 mDa |
|---|---|
| Measurement principle | Static Light Scattering with Debye Plot |
| Accuracy | +/- 10% |
| Measurement principle | Blue Label: N/A
Red Label: MADLS - Particle Concentration (Mie) |
|---|---|
| Concentration range | Blue Label: N/A
Red Label: 1x108 to 1x1012 particles/mL |
| Calibration type | Blue Label: N/A
Red Label: Single point system calibration only |
| Detector | Avalanche Photodiode |
|---|---|
| Laser safety | He-Ne (633 nm)
Blue label: 4 mW Max
Red label: 10 mW Max |
| Temperature control range | 0 °C - 120 °C 7 |
| Dimensions (W, D, H) | 322 mm x 565 mm x 245 mm |
| Weight | 19 kg |
| Power | AC 100-240 V, 50-60 Hz, 4.0 A |
| Power consumption | Max 100 W, Typical 45 W |
| Ambient conditions | +10°C to +35°C, 35 to 80% RH (Non-condensing) |
| Interface | USB 2.0 or higher |
| International standards | International Standards Organization
ISO22412:2025
ISO13099-2:2025
US Pharmacopoeia (USP)
430 – Particle Size Analysis by Dynamic Light Scattering
432 – Determination of Zeta Potential by Electrophoretic Light Scattering
729 – Globule Size Distribution in Lipid Injectable Emulsions
1153 – Drug Products Containing Nanomaterials
1154 – Liposome Drug Products
1430 – Analytical Methodologies Based on Scattering Phenomena – General
ASTM
D4001
E2490
E2865
E3247 |
| Notes | 1 - Water as dispersant
2 - Indicative data available for particle sizes greater than 10 μm when using Extended Size Range analysis and low volume disposable sizing cell accessory.
3 - Sample dependent
4 - Using patented diffusion barrier technique
5 - Measured using 15 kDa protein
6 - Measured using bile acid
7 - Dry nitrogen cell purge required for temperatures below dewpoint
8 - Accuracy 0.1°C at 25°C, 0.2°C at 0°C, 0.5°C at 90°C
9 - Recommended upper size range for MADLS is 500nm diameter
|
|---|
Empowering scientists, one automated test at a time
Viscosity measurement with speed, simplicity and accuracy.
Automate your pH titrations
Eliminate sample cross contamination between zeta potential measurements using a completely disposable cell.
Reusable solvent resistant cell.
Save time and effort by measuring zeta potential with little or no dilution.
Glass cuvette for use with dip cell
Glass cuvette for batch measurements
Disposable polystyrene cuvettes
Low-volume quartz batch cuvette for size and molecular weight measurements.
Disposable plastic micro cuvette, for size measurement at 173° (NIBS) optics only
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When accuracy, clarity, and trust in your data matter, Zetasizer Ultra delivers. See how it can transform your workflow.
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